This is a non-surgical, minimally invasive technique for men with Peyronie’s Disease. It involves injecting a medical substance called collagenase directly into the scar tissue which can cause the penile curvature.


The procedure is performed in the outpatient setting.

You will need an initial consultation to assess the degree of curvature and point of maximum curvature.

An injection to create an erection is given to you to enable the consultant to perform the measurements.

Two further outpatient appointments are made for you within 7 days of each other. You will receive an injection of Collagenase into the scar tissue at each of these appointments.

The consultant will need to stretch your penis manually and based on his previous measurements and feeling for the scar, he will inject directly into the scar tissue.


You will experience some discomfort, swelling and bruising for up to a week after each injection.

Simple painkillers can be taken once you are home.

The consultant will apply a pressure bandage to your penis which needs to be kept in place for approximately 6 hours post injection.

Try to elevate your penis with padding or gauze to help alleviate swelling and bruising.

You should abstain from sexual penetrative intercourse for six weeks. Having erections during this time is advised though.

The consultant/nurse will advise you on how to use the vacuum device therapy following your second injection.

You may drive yourself home.